منابع مشابه
Sub- and super-fidelity as bounds for quantum fidelity
We derive several bounds on fidelity between quantum states. In particular we show that fidelity is bounded from above by a simple to compute quantity we call super–fidelity. It is analogous to another quantity called sub–fidelity. For any two states of a two– dimensional quantum system (N = 2) all three quantities coincide. We demonstrate that sub– and super–fidelity are concave functions. We ...
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The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are attenuated in a mouse model of poliovirus. Given these results, it was surprising that the nucleotide ...
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Complexins (CPXs I-IV) presumably act as regulators of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, but their function in the intact mammalian nervous system is not well established. Here, we explored the role of CPXs in the mouse auditory system. Hearing was impaired in CPX I knock-out mice but normal in knock-out mice for CPXs II, III, IV, and III...
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Besides the established central role of poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 in the maintenance of genomic integrity, accumulating evidence indicates that poly(ADP-ribosyl)ation may modulate epigenetic modifications under physiological conditions. Here, we provide in vivo evidence for the pleiotropic involvement of Parp-2 in both meiotic and postmeiotic processes. We show that Parp...
متن کاملFidelity of human immunodeficiency virus type I reverse transcriptase in copying natural RNA.
The in vitro fidelity of reverse transcriptase from human immunodeficiency virus type I (HIV-1 RT) upon copying an RNA template was measured using the phi Xam 16 reversion assay. A phi X174 sequence harboring the amber 16 codon was cloned into a transcription vector. RNA obtained from transcription by bacteriophage T7 RNA polymerase was used as a template for RNA-directed DNA synthesis by HIV-1...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 2015
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.7556